Liver Enzymes Explained: What Elevated ALT and AST Really Mean
By the HealthN Insights Editorial Team · Published June 29, 2026 · Researched using CDC, WHO, and peer-reviewed sources You open the patient portal expecting nothing. Your annual physical was routine — you feel fine, you exercise, you rarely drink. Then two numbers jump out, flagged in urgent red: ALT and AST, both marked "high." A message from the doctor's office asks you to book a follow-up. A test you weren't worried about an hour ago suddenly has your full attention. It's a familiar gut-punch: abnormal results you weren't braced for. Within minutes you're Googling medical abbreviations, falling down rabbit holes about liver disease, and mentally cataloging every glass of wine from the past year. Here's what actually happens when those numbers climb above the reference range — and why context matters more than the numbers themselves. What ALT and AST Actually Measure These enzymes aren't mysterious. They're working proteins that ...